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Gajewski, Thomas F.

One or more keywords matched the following items that are connected to Gajewski, Thomas F.

Item Type	Name
Concept	Signal Transduction
Academic Article	Differential regulation of murine T lymphocyte subsets.
Academic Article	B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro.
Academic Article	Apoptosis meets signal transduction: elimination of a BAD influence.
Academic Article	Blocked Ras activation in anergic CD4+ T cells.
Academic Article	B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.
Academic Article	Cutting edge: differentiation of antitumor CTL in vivo requires host expression of Stat1.
Academic Article	Helper T cell differentiation is controlled by the cell cycle.
Academic Article	Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
Academic Article	CD28 is not required for c-Jun N-terminal kinase activation in T cells.
Academic Article	Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).
Academic Article	Differential activation of murine TH1 and TH2 clones.
Academic Article	Differential Ras signaling via the antigen receptor and IL-2 receptor in primary T lymphocytes.
Academic Article	Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.
Academic Article	Molecular regulation of T-cell anergy.
Academic Article	Protein kinase Ctheta focusing at the cSMAC is a consequence rather than cause of TCR signaling and is dependent on the MEK/ERK pathway.
Academic Article	Costimulatory and coinhibitory receptors in anti-tumor immunity.
Academic Article	Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.
Academic Article	Innate immune sensing of cancer: clues from an identified role for type I IFNs.
Academic Article	Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells.
Academic Article	Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro.
Academic Article	Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer.
Academic Article	Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
Academic Article	Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A.
Academic Article	Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.
Academic Article	Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.
Academic Article	An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.
Academic Article	"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.
Academic Article	Control of T lymphocyte signal transduction through clonal anergy.
Academic Article	Type I interferon response and innate immune sensing of cancer.
Academic Article	Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).
Academic Article	STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
Academic Article	New perspectives on type I IFNs in cancer.
Academic Article	Innate immune recognition of cancer.
Academic Article	Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.
Academic Article	Melanoma-intrinsic ß-catenin signalling prevents anti-tumour immunity.
Academic Article	Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer.
Academic Article	Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy.
Academic Article	Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection.
Academic Article	Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.
Academic Article	Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer.
Academic Article	NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells.
Academic Article	Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.
Academic Article	Innate immune signaling and regulation in cancer immunotherapy.
Academic Article	Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Academic Article	STING pathway agonism as a cancer therapeutic.
Academic Article	Secondary resistance to immunotherapy associated with ß-catenin pathway activation or PTEN loss in metastatic melanoma.
Academic Article	Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-?-signaling mutant cancer cells.

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Signal Transduction